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In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

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High-dose studies show notable HbA1c reductions, significant weight loss, and improvements in lipid profiles and blood pressure, supporting its role in multi-hormone metabolic investigations